Mouse Models for Drug Discovery: Methods and Protocols
Methods in Molecular Biology, Volume 602
Mice provide excellent model systems for the drug discovery process, being versatile, easy to use and having a genome remarkably similar to that of humans. For those less familiar with mice as experimental models, this book, written by experts in the field, provides background, a collection of general technical methods and specific disease topics such as type 1 and 2 diabetes, cardiovascular disease, arthritis, skin disorders, cancer, the use of behavioural models for depression and anxiety, neurodegenerative diseases, neuromuscular diseases and infectious diseases. The book also includes essential background about mouse genetic engineering, covers the classic outbred and inbred mice as well as the latest genetically-engineered mouse models and presents guidance for experimental design, techniques, and approaches to data analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy-to-use, this book is an essential lab resource for those contemplating the use of mice as well as for those already working with them.
Humana Press,
an imprint of Springer Science + Busine ss media Secaucus, NJ, USA
Humana Press Inc
