Compound libraries targetting kinases and protein-protein interactions

kinases and protein-protein interactions

Four biologically targetted libraries containing novel, drug-like compounds that specifically target kinases and protein-protein interactions have been launched by BioFocus – a provider of gene-to-clinical candidate drug discovery services. Three new SoftFocus kinase libraries (SFK61, SFK62 and SFK63) target either the hinge region, allosteric sites or novel binding modes and this collection has been independently determined to have the greatest population of kinase-like molecules available for screening. The company’s second Helix Mimetic library (HM02) is based on a novel structure that interacts with protein helices.  This library is designed to inhibit protein-protein interactions, but can also target other helical recognition motifs such as the pore region of ion channels. These focussed libraries have delivered outstanding success in drug discovery programmes, which originates from a fundamental belief in designing and synthesising library molecules that are tailored to the biological target or family of interest.

BioFocus DPI

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