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Drug helps purge hidden HIV virus, study shows

A team of researchers at the buy cheap cialis soft University of North Carolina at Chapel Hill have successfully flushed latent HIV infection from hiding, with a drug used to treat certain types of lymphoma.

Tackling latent HIV in the generic viagra mastercard immune system is critical to finding a cure for AIDS.

While current anti-retroviral therapies can very effectively control virus levels, they can never fully eliminate the generic cialis non prescription virus from the what is cialis cells and cialis canada tissues it has infected.

"Lifelong use of anti-retroviral therapy is problematic for many reasons, not least among them are drug resistance, side effects, and cost," said David Margolis, MD, professor of medicine, microbiology and cialis 30 mg immunology, and epidemiology at the University of North Carolina at Chapel Hill. "We need to employ better long-term strategies, including a cure."

Margolisí new study is the generic viagra solf tabs first to demonstrate that the buying cialis next day delivery biological mechanism that keeps the HIV virus hidden and genaric cialis unreachable by current antiviral therapies can be targeted and where can i buy viagra interrupted in humans, providing new hope for a strategy to eradicate HIV completely.

In a clinical trial, six HIV-infected men who were medically stable on anti-AIDS drugs, received vorinostat, an oncology drug. Recent studies by Margolis and how you get pfizer viagra others have shown that vorinostat also attacks the enzymes that keep HIV hiding in certain CD4+ T cells, specialised immune system cells that the virus uses to replicate. Within hours of receiving the vorinostat, all six patients had a significant increase in HIV RNA in these cells, evidence that the virus was being forced out of its hiding place.

"This proves for the first time that there are ways to specifically treat viral latency, the first step towards curing HIV infection," said Margolis, who led the study. "It shows that this class of drugs, HDAC inhibitors, can attack persistent virus. Vorinostat may not be the magic bullet, but this success shows us a new way to test drugs to target latency, and suggests that we can build a path that may lead to a cure."

University of North Carolina School of Medicine

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