Biotech International: Drug helps purge hidden HIV virus, study shows Hospital devices Medical devices

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Drug helps purge hidden HIV virus, study shows



A team of researchers at the University of North Carolina at Chapel Hill have successfully flushed latent HIV infection from hiding, with a drug used to treat certain types of lymphoma

Tackling latent HIV in the immune system is critical to finding a cure for AIDS.

While current anti-retroviral therapies can very effectively control virus levels, they can never fully eliminate the buy real viagra online virus from the cells and cialis online tissues it has infected

"Lifelong use of anti-retroviral therapy is problematic for many reasons, not least among them are drug resistance, side effects, and cost," said David Margolis, MD, professor of medicine, microbiology and immunology, and epidemiology at the cheap cialis online canadian pharmacy University of North Carolina at Chapel Hill"We need to employ better long-term strategies, including a cure."

Margolisí new study is the first to demonstrate that the biological mechanism that keeps the HIV virus hidden and buy viagra canada online unreachable by current antiviral therapies can be targeted and interrupted in cialis pharmacy online humans, providing new hope for buy viagra online a strategy to eradicate HIV completely.

In a clinical trial, six HIV-infected men who were medically stable on cialis online anti-AIDS drugs, received vorinostat, an oncology drugRecent studies by Margolis and others have shown that vorinostat also attacks the generic viagra online pharmacy enzymes that keep HIV hiding in viagra online certain CD4+ T cells, specialised immune system cells that the virus uses to replicateWithin hours of receiving the vorinostat, all six patients had a significant increase in HIV RNA in these cells, evidence that the virus was being forced out of its hiding place.

"This proves for the first time that there are ways to specifically treat viral latency, the first step towards curing HIV infection," said Margolis, who led the study"It shows that this class of drugs, HDAC inhibitors, can attack persistent virusVorinostat may not be the buy viagra online overnight delivery magic bullet, but this success shows us a new way to test drugs to target latency, and suggests that we can build a path that may lead to a cure."

University of North Carolina School of Medicine


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Hospital devices Medical devices

The online source of technology & product information for life scientist & bioentrepreneurs

E-newsflash: Details

Drug helps purge hidden HIV virus, study shows



A team of researchers at the University of North Carolina at Chapel Hill have successfully flushed latent HIV infection from hiding, with a drug used to treat certain types of lymphoma.

Tackling latent HIV in the immune system is critical to finding a cure for AIDS.

While current anti-retroviral therapies can very effectively control virus levels, they can never fully eliminate the virus from the cells and tissues it has infected.

"Lifelong use of anti-retroviral therapy is problematic for many reasons, not least among them are drug resistance, side effects, and cost," said David Margolis, MD, professor of medicine, microbiology and immunology, and epidemiology at the University of North Carolina at Chapel Hill. "We need to employ better long-term strategies, including a cure."

Margolisí new study is the first to demonstrate that the biological mechanism that keeps the HIV virus hidden and unreachable by current antiviral therapies can be targeted and interrupted in humans, providing new hope for a strategy to eradicate HIV completely.

In a clinical trial, six HIV-infected men who were medically stable on anti-AIDS drugs, received vorinostat, an oncology drug. Recent studies by Margolis and others have shown that vorinostat also attacks the enzymes that keep HIV hiding in certain CD4+ T cells, specialised immune system cells that the virus uses to replicate. Within hours of receiving the vorinostat, all six patients had a significant increase in HIV RNA in these cells, evidence that the virus was being forced out of its hiding place.

"This proves for the first time that there are ways to specifically treat viral latency, the first step towards curing HIV infection," said Margolis, who led the study. "It shows that this class of drugs, HDAC inhibitors, can attack persistent virus. Vorinostat may not be the magic bullet, but this success shows us a new way to test drugs to target latency, and suggests that we can build a path that may lead to a cure."

University of North Carolina School of Medicine


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Sponsored links: